Our story

Four decades of backing bold genetic science

UK Registered Charity No. 1211119 — a strategic investor in genomic medicine, working where discovery meets the clinic.

Who we are

From a paediatric research unit to the genomics revolution

The Generation Trust was originally founded in 1983 to support medical research at the Paediatric Research Unit at Guy's Hospital. We became a Charitable Incorporated Organisation (CIO) in 2025, and today we work closely with the Department of Medical & Molecular Genetics at King's College London.

We primarily fund pioneering research with real-world clinical applications — improving genetic diagnosis, carrier screening and, potentially, therapeutic interventions within the Genomics Medicine Group (GMG).

Our journey

Milestones along the way

1983

Founded at Guy's Hospital

Registered with the Charity Commission on 18 April 1983 to support genetic research into paediatric conditions at the Paediatric Research Unit.

1990s–2010s

Evolving with genomics

As genomic science advanced, so did our focus — funding gene discovery, diagnosis and the researchers driving the field forward.

2025

Becoming a CIO

We became a Charitable Incorporated Organisation, strengthening our governance for the next generation of funding.

Today

A strategic partner to King's College London

We fund the full trajectory of genomic innovation — from identifying genetic mechanisms to precision clinical tools.

How we work

Lean, responsive and catalytic

Early-career focus

We help promising researchers establish themselves and compete for larger grants, filling a critical funding gap.

Rapid response

A lean structure and close ties to Guy's Hospital let us react quickly to funding requests when timing matters most.

Catalytic grants

Our funding helps unlock major institutional and government investment, multiplying the impact of every donation.

Governance

Current trustees

A board bringing together decades of scientific, clinical and organisational expertise.

Portrait of John Buckle

John Buckle

Trustee

John originally trained as a scientist with a PhD in Physiology from Cambridge University. His career in the pharmaceutical industry started as a clinical researcher, designing and running clinical trials, and he subsequently moved into marketing, general management, business development and strategy with a number of the largest pharmaceutical companies.

He has been a board member of a number of pharmaceutical and biotech companies and has run three different businesses. In recent years he has been a self-employed interim manager and business consultant, advising and supporting the growth and development of smaller biotech and pharmaceutical companies.

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Portrait of Professor Francis Drobniewski

Prof. Francis Drobniewski

Trustee

Francis is Professor of Global Health and Tuberculosis at Imperial College, London (ICL), a clinical and public health microbiologist and physician (accredited in Microbiology, Virology and Immunology) and Consultant Microbiologist at University Hospitals Dorset. He was a Wellcome Fellow based in New York City and Director of the UK National Mycobacterium Reference Laboratory (1996–2015), providing public health and clinical advice, and has 25 years' experience leading and co-leading complex respiratory disease research programmes focusing on TB/HIV infections, COVID-19, biomarker discovery, molecular and genomic-based diagnostics and antimicrobial drug resistance detection, integrating clinical, biological and social themes. Much of his research and training activity is focused in low- and middle-income countries, especially in Eastern Europe and Africa. He has provided clinical care as a resident and Consultant, primarily for patients with tuberculosis and/or AIDS, at King's College Hospital, Barts NHS Trust and other south London hospitals.

He was a Board Non-Executive Director for Kent Community Hospital Foundation Trust (2018–2022), including the COVID Clinical Reference Group, Vice Chair of the Quality Committee, and a member of the Strategic Workforce, Remuneration and Audit/Risk Committees. He founded and remains a member of the ECDC TB Reference Lab Network (2009 onwards) and served on several clinical and public health ECDC committees. He has held several roles with the World Health Organisation focusing on the diagnosis and treatment of drug-resistant bacterial infections and the management of multidrug-resistant tuberculosis and HIV-TB, including Director of a WHO Supra-national Reference Laboratory, member of the WHO Strategic Advisory Group, and Chair of the WHO European Laboratory Initiative on TB, HIV and viral hepatitis.

He was made a Fellow of the European Society of Clinical Microbiology and Infectious Diseases in 2017 and elected a Fellow of the American Academy of Microbiology in 2025.

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Portrait of Peter Curteis

Peter Curteis

Trustee

Peter is a partner at the investment firm Brown Advisory.

Portrait of Richard Freeman

Richard Freeman

Trustee

Richard Freeman is Global Head of Trading at CMC Markets in London. Prior to this he held a variety of trading roles in leading investment banks, most recently as a Managing Director in Equity Derivatives trading at Morgan Stanley in London.

Richard has a BA in Economics from the University of Sheffield and is married with two teenage children.

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Portrait of Professor Chris Mathew

Prof. Chris Mathew

Trustee

Chris Mathew was born and raised in South Africa, where he graduated with a BSc Honours in Biochemistry. He then moved with his wife Denise to London, where he obtained a PhD in molecular biology at the Institute of Cancer Research. He later worked with Sir Bruce Ponder at the Institute on mapping genes for hereditary cancers, and moved to the Department of Medical and Molecular Genetics in 1989 as Director of the newly formed NHS DNA Diagnostic Laboratory. He was appointed Professor of Molecular Genetics in the Department in 1999 and served in various roles including Deputy Head and acting Head of Department until his full retirement in January 2020, when he was appointed Professor Emeritus.

Chris was keen to develop the emerging field of Cancer Genetics in his native South Africa and was appointed Distinguished Professor in Human Genetics at the Sydney Brenner Institute for Molecular Bioscience at the University of the Witwatersrand in Johannesburg in 2015. His research group focuses on the genetics and genomics of common cancers in the Black South African population, and on the application of molecular technology and knowledge to improved diagnosis and treatment for African cancer patients.

Chris has served on many professional committees and research grant panels, including Chair of the Special Advisory Committee on Genetics for the Royal College of Pathologists, member of the Wellcome Trust Molecular and Cell Panel, Vice-Chair of Cancer Research UK's Biological Science Committee and Chair of CRUK's International Cancer Genome Review Panel.

He was elected a Fellow of the Academy of Medical Sciences (UK) in 2011 in recognition of his discovery of genes involved in susceptibility to cancer and inflammatory bowel disease. He is delighted to contribute to the further success of the Department of Medical and Molecular Genetics at Guy's in his role as a Trustee for The Generation Trust.

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Past trustees

Portrait of Andrew Ross

Andrew Ross OBE

Trustee

Andrew Ross was one of the founding trustees of The Generation Trust in the 1980s. A retired charity executive, until 2013 he was Chief Executive of The Children's Trust, a charity providing care, education and therapeutic rehabilitation for children with disabilities and complex health needs. He was subsequently Director of The Peter Harrison Foundation, a grant-giving charity with a particular focus on sport for disabled people.

He has been a trustee of several other charities including The Edward Gostling Foundation, Lifelites, the Child Health Research CIO and the Masonic Charitable Foundation, where he was Chair of the Charity Grants Committee. He is a fellow and former chair of the Chartered Institute of Fundraising.

He has a degree in modern languages from Cambridge University and an MBA from INSEAD, Fontainebleau. He was awarded an OBE in the Queen's Birthday Honours List for 2013. He lives near Horsham, West Sussex, with his wife, Alison.

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